April 27, 2021
Potential advancements in treatment of PTSD and PTSD-related cardiovascular disease
A new study reveals that renin-angiotensin system (RAS) genes within the amygdala—the brain region important for traumatic memory processing—express differently when the brain develops fearful memories, such as when people undergo traumatic stress. Researchers have found that medication may potentially be used as a pharmacological blockade of the angiotensin type 1 receptor, thereby improving components of fear memory as assessed by freezing behavior. The research team from George Washington University in Washington, D.C., will present their findings virtually at the American Physiological Society's (APS) annual meeting at Experimental Biology 2021.
Post-traumatic stress disorder (PTSD) is a strong predictor of cardiovascular disease (CVD), the leading cause of death in the U.S. The RAS gene, which is critical for blood pressure regulation, is seen as a potentially important link between PTSD and CVD. This study examined the RAS within areas of the brain responsible for processing traumatic or fear-related memories and its effects on cardiovascular regulation. The researchers hoped that it would lead to new treatment and prevention strategies for both PTSD and PTSD-related CVD risk.
Current treatment options for PTSD are limited, and the causes of PTSD-CVD risk is unclear. These pre-clinical findings shed light on a potential therapeutic target and extend the current understanding for the regulation of brain RAS during fear learning and memory recall processes that are impaired in PTSD.
Researchers discover protective factor against psychological trauma More information: Abstract title: "Dynamic regulation of brain renin angiotensin system during fear memory reconsolidation" Provided by Experimental Biology Citation: Potential advancements in treatment of PTSD and PTSD-related cardiovascular disease (2021, April 27) retrieved 29 April 2021 from https://www.medican-health.com/news/2021-04-potential-advancements-treatment-ptsd-ptsd-related.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. 2 shares
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